Macrophage scavenger receptor-knockout mice.
نویسندگان
چکیده
منابع مشابه
Onion-bulb formation after a single compression injury in the macrophage scavenger receptor knockout mice.
Onion-bulb (OB) formation is often encountered in acquired neuropathies such as chronic inflammatory demyelinating polyradiculoneuropathy and diabetic neuropathy and is believed to require repeated injuries to peripheral nerves. Although this suggests that remaining damaged cell membranes, including myelin debris, might trigger OB formation, the molecular mechanism remains unclear. In this stud...
متن کاملMacrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice.
OBJECTIVE Mice null for both apolipoprotein (apo)E and scavenger receptor (SR)-BI (DKO) develop severe hypercholesterolemia, occlusive coronary atherosclerosis, myocardial infarction, and premature death. The current study examines the ability of macrophage apoE to improve the dyslipidemia, reduce atherosclerosis, and rescue the lethal phenotype of DKO mice. METHODS AND RESULTS Initially, bon...
متن کاملMacrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis.
In atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is modified (eg, oxidized), and these modified lipoproteins activate endothelial cells, which attract circulating monocytes. These monocytes enter the vessel wall, differentiate into macrophages, and subject the modified lipoproteins to endocytosis throu...
متن کاملIncreased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL.
OBJECTIVE In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated. METHODS AND RESULTS SR-BI deficiency resulted in 1.4-fold (P<0.001) and 1.6-fold (P<0.01) lower serum paraoxonase and arylesterase activity of PON1, respective...
متن کاملPhosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice.
It has been suggested that binding of phosphorothioate oligodeoxynucleotides (P=S ODNs) to macrophage scavenger receptors (SR-AI/II) is the primary mechanism of P=S ODN uptake into cells in vivo. To address the role of scavenger receptors in P=S ODN distribution in vivo, several pharmacokinetic and pharmacological parameters were compared in tissues from scavenger receptor knockout mice (SR-A-/...
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ژورنال
عنوان ژورنال: The journal of the Japanese Society of Lymphoreticular Tissue research
سال: 1998
ISSN: 1883-681X,1342-9248
DOI: 10.3960/jslrt1997.38.227